Why is Covid 19 mild in some, life threatening in others?

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Severity of Covid 19 is related to a inflammatory storm that damages lungs and other organs in addition to the viral damage to the cells. Changes in the different components of the immunity due to certain risk factors leads to some individuals more vulnerable to this storm resulting in developing severe to life threatening Corona infection compared to others. Viral load at the time of exposure also plays a role. Moreover some viral mutations induce more severe infection than others

Following are the risk factors:

Co-morbid medical conditions

– Obesity
– Diabetes
– Hypertension
– Cardiovascular disease
– Chronic Renal diseases
– Immunodeficiency diseases

Medications usage

– Immuno suppressant medications
– Cancer treatment
– Steroids
– Long term pain killers (NSAID)

Some risk factors reduce lung function increasing susceptibility to severe infection:

Chronic obstructive pulmonary diseases
Cigarette Smoking..

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